prevalence of hepatitis g virus among hemodialysis and kidney transplant patients in khuzestan province, iran

نویسندگان

ali reza samarbaf-zadeh health research institute, infectious and tropical diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; virology department, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

manochehr makvandi health research institute, infectious and tropical diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; virology department, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

ahmad hamadi department of parasitology, iran university of medical sciences, tehran, ir iran

gholam abbas kaydani health research institute, infectious and tropical diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; allied health sciences school, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; health research institute, infectious and tropical diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran. tel: +98-6133738317

چکیده

patients and methods five hundred and sixteen serum samples of the patients undergoing hemodialysis and kidney transplantation from various cities of khuzestan province were collected. anti-hepatitis g e2 antibodies were investigated by elisa method. rnas were extracted from serums and hepatitis g rna was detected by rt-pcr. results of the 516 samples, 38 (7.36%) specimens were positive for anti-hgv by elisa. all of these elisa positive samples were negative for hgv genome by rt-pcr. of the remaining 478 elisa negative samples, 16 (3.14%) samples were positive by rt-pcr. conclusions hepatitis g virus was not prevalent in the patients undergoing hemodialysis and kidney transplantation in khuzestan province. although reports indicated high frequency of co-infection of hgv with hepatitis b and c viruses, in the current research, co-infection of hgv with b and c was not considerable. since different groups and subtypes of hgv are reported, periodic epidemiologic evaluation of hgv and its co-infection with other hepatitis viruses is suggested in other populations such as the patients with thalassemia; however, periodic epidemiologic monitoring of hgv may be helpful to control future potential variations of the virus. background hepatitis g virus (hgv) is a member of flaviviridae. prevalence of hgv in healthy people is very low, but this virus is more prevalent in patients with hepatitis. besides, relative frequency of hgv in patients undergoing hemodialysis, and kidney recipients is very high. the role of hgv in pathogenesis is not clear. since this virus cannot be cultivated, molecular techniques such as revers transcription polymerase chain reaction (rt-pcr) is applied to detect hgv. objectives the current study aimed to investigate the prevalence of hgv using determination of e2, viral envelope antigen, antibodies and the rna by enzyme linked immunosorbent assay (elisa) and rt-pcr techniques. the rational of the study was to determine the prevalence of hgv in patients undergoing hemodialysis and kidney transplantation in khuzestan province, iran.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prevalence of Hepatitis G Virus Among Hemodialysis and Kidney Transplant Patients in Khuzestan Province, Iran

BACKGROUND Hepatitis G virus (HGV) is a member of Flaviviridae. Prevalence of HGV in healthy people is very low, but this virus is more prevalent in patients with hepatitis. Besides, relative frequency of HGV in patients undergoing hemodialysis, and kidney recipients is very high. The role of HGV in pathogenesis is not clear. Since this virus cannot be cultivated, molecular techniques such as R...

متن کامل

Prevalence of hepatitis C and B infection and HC V genotypes among hemodialysis patients in Khuzestan province, southwest Iran.

Hepatitis B (HBV) and C (HCV) virus infection are the most important infections transmitted by the parenteral route in hemodialysis patients. This study is the first report of prevalence of viral hepatitis and hepatitis C virus genotypes in southwest Iran among hemodialysis patients. A cross-sectional study was carried out among 214 hemodialysis patients of the Central hemodialysis unit, from M...

متن کامل

A study on genotypes of hepatitis B virus among hemodialysis patients in Khuzestan province

Introduction and objective: Hepatitis B virus (HBV) is a member of Hepadnaviridae and a major causative agent of chronic and acute hepatitis, liver cirrhosis and hepatocellular carcinoma. Genotype determination of HBV is based on PCR-RFLP and sequencing of genome of the virus. The genotype formation is mainly due to mutations of HBV precore, S, and YMDD (tyrosine-methionine-aspartate-aspartate ...

متن کامل

Secondary hyperparathyroidism in chronic hemodialysis patients in Khuzestan province, Iran

Introduction End-stage renal disease (ESRD) is a life-threatening disease with significant complication and the incidence and prevalence of this disease have signi ficantly increased in recent years and imposes a major social and economic burden for healthcare systems (1,2). As seen worldwide, it is well-established that diabetic nephropathy particularly from type 2 diabetes, and hypertensive n...

متن کامل

Infections Among Multi-transfused Patients in Southwest Iran, Khuzestan Province

Background: Transfusion-transmi!ed infec"ons (TTIs) con"nue to be a problem in many parts of the world and mul"-transfused pa"ents are at a par"cularly increased risk for TTIs. The aim of this study was to determine the prevalence of Hepa""s C, Hepa""s B, and human immunodeficiency virus (HIV) infec"ons among mul"-transfused pa"ents in Khuzestan Province. Materials and Methods: A cross-sec"onal...

متن کامل

Seroprevalence of hepatitis B virus among hemodialysis patients in Bushehr province, southern Iran

BACKGROUND Hepatitis B virus (HBV) infection is still reported from adult hemodialysis units. OBJECTIVES To determine the prevalence of anti-HBs antibody in hemodialysis patients and the correlation between levels of anti-HBs antibody with other factors. PATIENTS AND METHODS HBsAg, anti-HBs and anti-HBc antibodies level in 119 hemodialysis patients were evaluated by enzyme-linked immunosorb...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
jundishapur journal of microbiology

جلد ۸، شماره ۵، صفحات ۰-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023